immunosuppressive drugs for kidney transplantation
Immunosuppressive drugs are essential medications used to prevent rejection of the transplanted kidney. Here are some of the most commonly used immunosuppressive drugs for kidney transplantation:
1. Calcineurin inhibitors (CNI):
Drug examples include cyclosporine, tacrolimus. These drugs decrease the activity of the immune system by blocking a protein called calcineurin, which is involved in the activation of T cells.
2. Antiproliferative agents:
Drug examples include azathioprine and mycophenolate. These drugs act by inhibiting the replication of cells, which slows down the immune response and limits the activity of cells that produce antibodies.
3. Corticosteroids:
Drug examples include prednisone and methylprednisolone. These drugs work by suppressing the immune system, reducing inflammation, and decreasing the production of antibodies.
4. mTOR inhibitors:
Drug examples include sirolimus and everolimus. These drugs act by inhibiting the activity of a protein called mTOR, which is involved in cell growth and division. They also limit the activity of T cells.
Most patients will receive a combination of these drugs to achieve the best possible outcome. It's important to note that immunosuppressive drugs can have side effects, and individual adjustments may be necessary based on the patient's response to the medications. Therefore, always follow the instructions of the doctor and take the prescribed drugs as directed. Regular monitoring and follow-up appointments will also be necessary to ensure the medications are working well and to detect any side effects.
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